Santa Fe Complex is hosting an "Art of Systems Biology" Show in the
Spring 2009 with Los Alamos National Lab. We're recruiting students
and mentors to learn about Systems Biology and develop models and
visualizations for the show and for projects in Supercomputing
Challenge <
http://challenge.nm.org>. Bill's talk is a first tutorial
on the subject.
The talk should also be of strong interest to folks in the agent-based
modeling community to potentially think about their models from a
Systems Biology perspective as an interaction graph model with graph-
rewriting rules.
Please come tomorrow!
---------------------
Systems Biology Introduction and Rule-based Modeling of Biochemical
Systems
SPEAKER: Bill Hlavacek, LANL Theoretical Biology and Biophysics, T-6
http://www.t6.lanl.gov/wish/LOCATION: Wed, Oct 21, 10:30a-12:30p @ Santa Fe Complex, 624 Agua Fria
<
http://www.sfcomplex.org>
ABSTRACT:
LANL researcher Bill Hlavacek hosts a WedTech talk on rule-based
modeling of biomechanical systems. This approach involves representing
molecules as structured objects (graphs) and molecular interactions as
(graph-rewriting) rules for transforming the attributes of these
objects.
The approach is notable in that it allows one to systematically
incorporate site-specific details about protein-protein interactions
into a model for the dynamics of a signal-transduction system, but the
method has other applications as well, such as following the fates of
individual carbon atoms in metabolic reactions. The consequences of
protein-protein interactions are difficult to specify and track with a
conventional modeling approach because of the large number of protein
phosphoforms and protein complexes that these interactions potentially
generate. In this tutorial talk, I will focus on how a rule-based
model is specified in the BioNetGen language (BNGL) and how a model
specification is analyzed using the BioNetGen software framework.
After Bill's talk, the Wedtech@sfcomplex group will walk over to lunch
at El Tesoro at 12:30p
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