** reminder today **
title: Agent-Based Modeling of T Cells
speaker: Bin Hu
Department of Biology, University of New Mexico
Theoretical Division, Los Alamos National Laboratory
when: Wed, Feb 24 11am
where: Santa Fe Complex, 632 Agua Fria Street
Frito Pie lunch will be served. $5
Abstract: T lymphocytes, or T cells, play an important role in adaptive immunity. T cells recognize antigens via cell-surface receptor proteins. Two of the most important receptors are the T cell receptor (TCR) and CD28, a TCR co-receptor. Unlike receptors in many other signal transduction pathways, TCR and CD28 have no inherent kinase activity. Instead, TCR and CD28 recruit an array of cytoplasmic kinases to the inner surface of the cell membrane to initiate cytoplasmic signal transduction upon successful receptor-antigen recognition. The initial recognition event and recruitment of cytoplasmic kinases to receptors trigger a complex cascade of protein-protein interactions that involves both positive and negative feedbacks. In this talk, I will discuss recent work aimed at developing a predictive agent-based model for early events in TCR signaling. The model that we are building is based on using literature data to specify the model structure and using quantitative temporal phosphoproteomic data to constrain model parameters through fitting procedures. The model is perhaps the most detailed mechanistic hypothesis ever postulated for how TCR signaling works. I will also discuss the challenges of annotating and visualizing such a large, complicated model.
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