I think a lot of that could be sorted out from population-based statistical inference from whole genome sequencing and large biobanks.
From: Friam <[hidden email]> On Behalf Of
Barry MacKichan
Sent: Monday, January 25, 2021 8:09 AM
To: The Friday Morning Applied Complexity Coffee Group <[hidden email]>
Subject: Re: [FRIAM] tangent from uncanny valley
There used to be a lot of talk about “junk DNA” which doesn’t do anything, but I’ve gotten the impression (sorry, I can’t give references) that more recently the “junk DNA” does play a role.
Also, adjacency or propinquity of genes on a chromosome affects evolution (if I get one of the genes from a parent, I’m highly likely to get the other also). I have no idea if it plays a role during the life of
a cell. I don’t know anything about how sexual reproduction goes about building a new chromosome by selecting pieces from the chromosomes of the parents, but on the face of it, changing the layout (or in mathematical terms, the metric) could lead to omission
or duplication errors in the result.
TL;DR Be careful what you wish for.
—Barry
On 22 Jan 2021, at 18:37, Marcus Daniels wrote:
Most of the human genome doesn't express as proteins, so there should be lots of room to store stuff.
Such technology is hardly science fiction, it's even FDA approved!
https://www.fda.gov/news-events/press-announcements/fda-approves-novel-gene-therapy-treat-patients-rare-form-inherited-vision-loss
-----Original Message-----
From: Friam <[hidden email]> On Behalf Of Prof David West
Sent: Friday, January 22, 2021 2:43 PM
To: [hidden email]
Subject: [FRIAM] tangent from uncanny valley
The idea of posthuman came up (yes it was me) in another thread. This article https://www.nature.com/articles/s41589-020-00711-4 opens an interesting door: "reprogramming" DNA by inserting new data into living DNA. After all a program is just another form of data. This might be orthogonal to genetic (re)engineering.
davew
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