A couple articles in this week’s Science relating to the programmability of cells.
http://science.sciencemag.org/content/361/6408/eaap8987
“This enables the design of cycles and developmental networks for engineering applications that require that cells exist in a particular state for an unspecified amount of time. For example, therapeutic cells
could be built to sense transient stimuli, such as throughout the gastrointestinal tract, and switch to a new state when the next signal is encountered. There are similar applications for diagnostic cells (48,
76–81), pathways to complex
chemicals and materials that require cycles of ordered operations (82), and sentinel plants and microbes with responsive traits (31,
83,
84).”
http://science.sciencemag.org/content/361/6408/1252
“For example, existing cancer-detection circuits (66,
67) could conditionally express CHOMP components to increase specificity and couple to protein-mediated inputs and outputs. Integrating these capabilities,
one can envision smart therapeutics or sentinels based on CHOMP circuits (68,
69).”
And those are the just some of the friendly applications.
Marcus
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