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Positively selected mutations

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David Eric Smith

Positively selected mutations

Have you guys seen this one:

https://www.biorxiv.org/content/10.1101/2020.04.29.069054v1

From Tanmoy Bhattacharya et al. Does not look like good news.

Eric

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gepr

Re: Positively selected mutations

Thanks! So, is the implication that even after we get some one vaccine, it may not be very effective? Like the flu. The flu shot Renee' gets at the hospital include 4 strains, whereas the ones I get at my clinic have only 3. So, does this talk of a mutating spike imply something similar will be the case 10 years from now with this one?

On 5/5/20 3:47 AM, David Eric Smith wrote:
> Have you guys seen this one:
>
> https://www.biorxiv.org/content/10.1101/2020.04.29.069054v1
>
> From Tanmoy Bhattacharya et al. Does not look like good news.

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uǝʃƃ ⊥ glen

Roger Critchlow-2

Re: Positively selected mutations

I think the implication is that there is a wave of more infectious covid building right now, just when everyone was looking for a chance to catch their breathand regroup.

-- rec --

On Tue, May 5, 2020, 11:47 AM uǝlƃ ☣ <[hidden email]> wrote:

Thanks! So, is the implication that even after we get some one vaccine, it may not be very effective? Like the flu. The flu shot Renee' gets at the hospital include 4 strains, whereas the ones I get at my clinic have only 3. So, does this talk of a mutating spike imply something similar will be the case 10 years from now with this one?

On 5/5/20 3:47 AM, David Eric Smith wrote:
> Have you guys seen this one:
>
> https://www.biorxiv.org/content/10.1101/2020.04.29.069054v1
>
> From Tanmoy Bhattacharya et al. Does not look like good news.

--
☣ uǝlƃ

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Marcus G. Daniels

Re: Positively selected mutations

It’s co-evolving with humans on a massive scale. This is just a tiny window into the possible diversity. There’s no telling. Hey, but sure, no task force. Who needs it?

From: Friam <[hidden email]> on behalf of Roger Critchlow <[hidden email]>
Reply-To: The Friday Morning Applied Complexity Coffee Group <[hidden email]>
Date: Tuesday, May 5, 2020 at 11:49 AM
To: The Friday Morning Applied Complexity Coffee Group <[hidden email]>
Subject: Re: [FRIAM] Positively selected mutations

I think the implication is that there is a wave of more infectious covid building right now, just when everyone was looking for a chance to catch their breathand regroup.

-- rec --

On Tue, May 5, 2020, 11:47 AM uǝlƃ ☣ <[hidden email]> wrote:

Thanks! So, is the implication that even after we get some one vaccine, it may not be very effective? Like the flu. The flu shot Renee' gets at the hospital include 4 strains, whereas the ones I get at my clinic have only 3. So, does this talk of a mutating spike imply something similar will be the case 10 years from now with this one?

On 5/5/20 3:47 AM, David Eric Smith wrote:
> Have you guys seen this one:
>
> https://www.biorxiv.org/content/10.1101/2020.04.29.069054v1
>
> From Tanmoy Bhattacharya et al. Does not look like good news.

--
☣ uǝlƃ

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Roger Critchlow-2

Re: Positively selected mutations

In reply to this post by Roger Critchlow-2

Actually, I should wait and read the whole paper before posting on my phone.

It's not a new new strain, it's the strain of Covid-19 that we've been dealing with on the east coast, a mutant first noticed in Italy in February, but it's been spreading quite successfully through Europe and North America.

-- rec --

On Tue, May 5, 2020 at 2:49 PM Roger Critchlow <[hidden email]> wrote:

I think the implication is that there is a wave of more infectious covid building right now, just when everyone was looking for a chance to catch their breathand regroup.

-- rec --

On Tue, May 5, 2020, 11:47 AM uǝlƃ ☣ <[hidden email]> wrote:
Thanks! So, is the implication that even after we get some one vaccine, it may not be very effective? Like the flu. The flu shot Renee' gets at the hospital include 4 strains, whereas the ones I get at my clinic have only 3. So, does this talk of a mutating spike imply something similar will be the case 10 years from now with this one?

On 5/5/20 3:47 AM, David Eric Smith wrote:
> Have you guys seen this one:
>
> https://www.biorxiv.org/content/10.1101/2020.04.29.069054v1
>
> From Tanmoy Bhattacharya et al. Does not look like good news.

--
☣ uǝlƃ

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Marcus G. Daniels

Re: Positively selected mutations

From another source (GenBank SRA data) I see several other mutations, A930T, which is in the HR1. This region in part determines how the virus fuses with a cell. They found one nearby at S943P. Here’s some context:

https://www.nature.com/articles/s41422-020-0305-x

I see some other mutations in the RBD (receptor binding domain), but they may not be proliferating. I don’t have the breadth of the GISAID data; they are “selective” (cough) about giving it to non-academics. The V483A mutation I also observed.

Marcus

From: Friam <[hidden email]> on behalf of Roger Critchlow <[hidden email]>
Reply-To: The Friday Morning Applied Complexity Coffee Group <[hidden email]>
Date: Tuesday, May 5, 2020 at 1:09 PM
To: The Friday Morning Applied Complexity Coffee Group <[hidden email]>
Subject: Re: [FRIAM] Positively selected mutations

Actually, I should wait and read the whole paper before posting on my phone.

-- rec --

On Tue, May 5, 2020 at 2:49 PM Roger Critchlow <[hidden email]> wrote:

I think the implication is that there is a wave of more infectious covid building right now, just when everyone was looking for a chance to catch their breathand regroup.

-- rec --

On Tue, May 5, 2020, 11:47 AM uǝlƃ ☣ <[hidden email]> wrote:

Thanks! So, is the implication that even after we get some one vaccine, it may not be very effective? Like the flu. The flu shot Renee' gets at the hospital include 4 strains, whereas the ones I get at my clinic have only 3. So, does this talk of a mutating spike imply something similar will be the case 10 years from now with this one?

On 5/5/20 3:47 AM, David Eric Smith wrote:
> Have you guys seen this one:
>
> https://www.biorxiv.org/content/10.1101/2020.04.29.069054v1
>
> From Tanmoy Bhattacharya et al. Does not look like good news.

--
☣ uǝlƃ

.-. .- -. -.. --- -- -..-. -.. --- - ... -..-. .- -. -.. -..-. -.. .- ... .... . ...
FRIAM Applied Complexity Group listserv
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